CuspAI’s total funding now exceeds $650 million, marking a nearly fivefold increase in valuation within less than a year. The Series B is led by Kleiner Perkins and NEA. New investors include Bezos Expeditions, Jeff Bezos’s investment vehicle, Lux Capital, AMD Ventures, Glade Brook Capital Partners, StepStone, the UK’s Sovereign AI Venture Fund, the Dutch development bank Invest-NL, John Doerr and Tru Arrow Partners. Returning investors include Temasek, Prosus, Northzone, Basis Set Ventures, Giant Ventures, Touring Capital and Phoenix Court.

The AI Materials Foundry brings together data, laboratory capacity, computing power and scientific expertise from its participating partners. Alongside AMD Ventures, chip equipment manufacturers Applied Materials, Lam Research and Tokyo Electron are joining as foundry partners, which the company says signals that the semiconductor industry sees value in AI-designed materials as a complement to its own research and development. Nvidia is providing computing infrastructure for the network, and Meta’s Fundamental AI Research team is contributing to the Universal Model for Atoms, or UMA, a model being deployed within the network. Abhi Talwalkar, a board member at AMD and chairman of Lam Research, has joined the advisory board, which already includes Turing Award winner Yann LeCun and Nobel laureate Geoffrey Hinton.

At the core of the network is MIRA, CuspAI’s proprietary AI platform for materials discovery. The platform links computational design to physical production: partners contribute specialised labs, measurement equipment and manufacturing expertise, allowing designed materials to actually be produced and tested. In addition to Nvidia and Meta, Samsung, Hyundai Motor Group, ASML, Hitachi High-Tech, Merck and Henkel are also part of the network. Application areas range from carbon capture and battery materials to chip materials, water purification and advanced manufacturing processes. In a project with Kemira, CuspAI says it screened 300 trillion potential molecular structures and delivered twenty validated candidates within six months, a process that would have taken years using conventional methods. John Giannandrea, former head of AI at Apple and Google, is coordinating development of the company’s US foundry operations.

CuspAI has offices in Cambridge, where it is headquartered, as well as in Amsterdam, Berlin, Tokyo and Singapore, with a London office set to open in 2026. Max Welling, a professor at the University of Amsterdam and known as a co-inventor of variational autoencoders and equivariant neural network architectures, serves as CTO at CuspAI. The Amsterdam team is based at Lab42 on Amsterdam Science Park. With Invest-NL, the Dutch development finance institution, joining as a new investor in the Series B, the round carries both a scientific and a financial Dutch connection, in a raise otherwise dominated by large American and international funds.